Product Description
Diphenhydramine ampules are a sterile, injectable form of diphenhydramine hydrochloride, a first-generation antihistamine. Each ampule contains 50 mg of diphenhydramine in 1 ml of solution.
Product Description
Diphenhydramine is a histamine H1 receptor antagonist. This means it blocks the action of histamine, a chemical released by the body during allergic reactions. It also has anticholinergic (drying) and sedative effects.
Indications
Diphenhydramine ampules are used to treat a variety of conditions, including:
- Allergic reactions: To relieve allergic reactions, especially severe ones like anaphylaxis, when oral medication is not possible.
- Motion sickness: To prevent and treat nausea, vomiting, and dizziness caused by motion sickness.
- Parkinsonism: To help control symptoms of Parkinson's disease, especially when oral medication is not possible.
Dosage Recommendation
The dosage of diphenhydramine should be determined by a healthcare professional and will vary depending on the patient's age, weight, and condition. It is typically administered intravenously or intramuscularly.
- Adults: 10 to 50 mg intravenously, or 100 mg intramuscularly, as needed. The maximum daily dose is 400 mg.
- Children: 5 mg/kg/24 hours or 150 mg/m²/24 hours, divided into four doses. The maximum daily dose is 300 mg.
Precautions
Diphenhydramine should be used with caution in patients with certain medical conditions, including:
- Glaucoma: Diphenhydramine can worsen glaucoma.
- Peptic ulcers: Diphenhydramine can worsen peptic ulcers.
- Prostatic hypertrophy: Diphenhydramine can worsen prostatic hypertrophy.
- Asthma: Diphenhydramine can worsen asthma.
- Cardiovascular disease: Diphenhydramine can worsen cardiovascular disease.
- Hypertension: Diphenhydramine can worsen hypertension.
Adverse Reactions
Diphenhydramine can cause a variety of side effects, some of which can be serious. The most common side effects include:
- Sedation: Drowsiness, sleepiness, dizziness, impaired coordination, fatigue, confusion.
- Anticholinergic effects: Dry mouth, nose, and throat; thickened bronchial secretions; urinary retention.
- Cardiovascular effects: Hypotension, headache, palpitations, tachycardia.
Severe side effects can include:
- Anaphylaxis: A severe allergic reaction that can be life-threatening.
- QT prolongation: A heart rhythm abnormality that can increase the risk of sudden cardiac death.
- Seizures: Diphenhydramine can cause seizures, especially in overdose.
- Toxic psychosis: Diphenhydramine can cause a state of confusion and disorientation that can be mistaken for psychosis.
It is important to report any side effects to your doctor, as they may need to adjust your treatment plan.
