Product Description
The combination tablet you described, containing Metformin 500mg and Sitagliptin 50mg, is a common medication used to manage type 2 diabetes.. It combines two different types of diabetes medications to effectively control blood sugar levels.
Understanding the Components:
- Metformin: This is a biguanide medication that works by reducing the liver's production of glucose (sugar) and improving the body's sensitivity to insulin. It also slows down the absorption of sugar from the intestines.
- Sitagliptin: This is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of incretins, natural hormones that help regulate blood sugar. Incretins stimulate the pancreas to produce more insulin, especially after meals, and also reduce the liver's production of glucose.
How it Works:
The combination of metformin and sitagliptin works synergistically to improve blood sugar control in people with type 2 diabetes. Metformin primarily addresses the liver's role in glucose production and intestinal absorption, while sitagliptin focuses on enhancing the body's natural insulin response, particularly after meals.
Uses:
Janumet is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is not used to treat type 1 diabetes.
Dosage and Administration:
The dosage of Janumet is typically individualized based on the patient's current regimen, effectiveness, and tolerability. The usual starting dose is 500mg of metformin and 50mg of sitagliptin taken twice daily with meals. The dosage may be adjusted gradually to achieve optimal blood sugar control.
Important Precautions:
- Lactic Acidosis: Metformin can cause a serious condition called lactic acidosis, particularly in patients with kidney or liver problems, heart failure, or dehydration. It's crucial to inform your doctor about any existing medical conditions.
- Kidney Function: Metformin can affect kidney function, so regular monitoring is necessary.
- Alcohol: Avoid excessive alcohol consumption while taking Janumet, as it can increase the risk of lactic acidosis.
- Surgery: You may need to temporarily stop taking Janumet before surgery or certain medical procedures involving contrast dyes.
- Pregnancy and Breastfeeding: Janumet is not recommended during pregnancy or breastfeeding.
Side Effects:
Common side effects of Janumet include:
- Nausea
- Vomiting
- Stomach upset
- Diarrhea
- Headache
- Weakness
- Metallic taste in the mouth
Important Note:
This information is not a substitute for professional medical advice. Always consult with your doctor or pharmacist before taking any medication. They can provide you with personalized guidance based on your specific health needs and medical history.
